Marnin L, Valencia LM, Bogale HN, Laukaitis-Yousey HJ, Rolandelli A, Ferraz CR, O'Neal AJ, Schmitter-Sánchez AD, Cuevas EB, Nguyen TT, Leal-Galvan B, Rickert DM, Mendes MT, Samaddar S, Butler LR, Singh N, Cabrera Paz FE, Wu-Chuang A, Oliver JD, Jameson JM, Munderloh UG, Oliva Chávez AS, Mulenga A, Park S, Serre D, Pedra JHF. Tick extracellular vesicles alter epidermal keratinocyte function. J Invest Dermatol. 2025 Sep 5;. doi: 10.1016/j.jid.2025.08.037. [Epub ahead of print] PubMed PMID: 40915408.

Trzeciak AJ, Liu ZL, Gatie M, Krebs AS, Saitz Rojas W, O'Neal AJ, Baako AK, Wang Z, Nelson J, Miranda IC, Uddin J, Lipshutz A, Xie J, Huang CL, Saavedra PHV, Hadjantonakis AK, Overholtzer M, Glickman MS, Subramanya AR, Vierbuchen T, Etchegaray JI, Lucas CD, Parkhurst CN, Perry JSA. WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity. Nat Commun. 2025 May 28;16(1):4945. doi: 10.1038/s41467-025-59901-0. PubMed PMID: 40436823; PubMed Central PMCID: PMC12120055.

Samaddar S, Rolandelli A*, O'Neal AJ*, Laukaitis-Yousey HJ, Marnin L, Singh N, Wang X, Butler LR, Rangghran P, Kitsou C, Cabrera Paz FE, Valencia L, R Ferraz C, Munderloh UG, Khoo B, Cull B, Rosche KL, Shaw DK, Oliver J, Narasimhan S, Fikrig E, Pal U, Fiskum GM, Polster BM, Pedra JHF. Bacterial reprogramming of tick metabolism impacts vector fitness and susceptibility to infection. Nat Microbiol. 2024 Sep;9(9):2278-2291. doi: 10.1038/s41564-024-01756-0. Epub 2024 Jul 12. PubMed PMID: 38997520; PubMed Central PMCID: PMC11926704.

Saavedra PHV, Trzeciak AJ, Lipshutz A, Daman AW, O'Neal AJ, Liu ZL, Wang Z, Romero-Pichardo JE, Rojas WS, Zago G, van den Brink MRM, Josefowicz SZ, Lucas CD, Anderson CJ, Rudensky AY, Perry JSA. Broad-spectrum antibiotics disrupt homeostatic efferocytosis. Nat Metab. 2024 Sep;6(9):1682-1694. doi: 10.1038/s42255-024-01107-7. Epub 2024 Aug 9. PubMed PMID: 39122784; PubMed Central PMCID: PMC7616532.

Singh N, Rolandelli A, O'Neal AJ, Butler LR, Samaddar S, Laukaitis-Yousey HJ, Butnaru M, Mohr SE, Perrimon N, Pedra JHF. Genetic manipulation of an Ixodes scapularis cell line. mBio. 2024 Mar 13;15(3):e0247923. doi: 10.1128/mbio.02479-23. Epub 2024 Feb 21. PubMed PMID: 38380961; PubMed Central PMCID: PMC10936194.

Rolandelli A, Laukaitis-Yousey HJ, Bogale HN, Singh N, Samaddar S, O'Neal AJ, Ferraz CR, Butnaru M, Mameli E, Xia B, Mendes MT, Butler LR, Marnin L, Cabrera Paz FE, Valencia LM, Rana VS, Skerry C, Pal U, Mohr SE, Perrimon N, Serre D, Pedra JHF. Tick hemocytes have a pleiotropic role in microbial infection and arthropod fitness. Nat Commun. 2024 Mar 8;15(1):2117. doi: 10.1038/s41467-024-46494-3. PubMed PMID: 38459063; PubMed Central PMCID: PMC10923820.

Butler LR, Singh N, Marnin L, Valencia LM, O'Neal AJ, Paz FEC, Shaw DK, Chavez ASO, Pedra JHF. The role of Rab27 in tick extracellular vesicle biogenesis and pathogen infection. Parasit Vectors. 2024 Feb 9;17(1):57. doi: 10.1186/s13071-024-06150-7. PubMed PMID: 38336752; PubMed Central PMCID: PMC10854084.

Forrest IS, O'Neal AJ, Pedra JHF, Do R. Cholesterol Contributes to Risk, Severity, and Machine Learning-Driven Diagnosis of Lyme Disease. Clin Infect Dis. 2023 Sep 18;77(6):839-847. doi: 10.1093/cid/ciad307. PubMed PMID: 37227948; PubMed Central PMCID: PMC10506776.

O'Neal AJ, Singh N, Rolandelli A, Laukaitis HJ, Wang X, Shaw DK, Young BD, Narasimhan S, Dutta S, Snyder GA, Samaddar S, Marnin L, Butler LR, Mendes MT, Cabrera Paz FE, Valencia LM, Sundberg EJ, Fikrig E, Pal U, Weber DJ, Pedra JHF. Croquemort elicits activation of the immune deficiency pathway in ticks. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2208673120. doi: 10.1073/pnas.2208673120. Epub 2023 May 8. PubMed PMID: 37155900; PubMed Central PMCID: PMC10193931.

Forrest IS, Petrazzini BO, Duffy Á, Park JK, O'Neal AJ, Jordan DM, Rocheleau G, Nadkarni GN, Cho JH, Blazer AD, Do R. A machine learning model identifies patients in need of autoimmune disease testing using electronic health records. Nat Commun. 2023 Apr 25;14(1):2385. doi: 10.1038/s41467-023-37996-7. PubMed PMID: 37169741; PubMed Central PMCID: PMC10130143.

Narasimhan S, Rajeevan N, Graham M, Wu MJ, DePonte K, Marion S, Masson O, O'Neal AJ, Pedra JHF, Sonenshine DE, Fikrig E. Tick transmission of Borrelia burgdorferi to the murine host is not influenced by environmentally acquired midgut microbiota. Microbiome. 2022 Oct 17;10(1):173. doi: 10.1186/s40168-022-01378-w. PubMed PMID: 36253842; PubMed Central PMCID: PMC9575305.

Oliva Chávez AS, Wang X, Marnin L, Archer NK, Hammond HL, Carroll EEM, Shaw DK, Tully BG, Buskirk AD, Ford SL, Butler LR, Shahi P, Morozova K, Clement CC, Lawres L, Neal AJO, Mamoun CB, Mason KL, Hobbs BE, Scoles GA, Barry EM, Sonenshine DE, Pal U, Valenzuela JG, Sztein MB, Pasetti MF, Levin ML, Kotsyfakis M, Jay SM, Huntley JF, Miller LS, Santambrogio L, Pedra JHF. Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection. Nat Commun. 2021 Jun 17;12(1):3696. doi: 10.1038/s41467-021-23900-8. PubMed PMID: 34140472; PubMed Central PMCID: PMC8211691.

O'Neal AJ, Singh N, Mendes MT, Pedra JHF. The genus Anaplasma: drawing back the curtain on tick-pathogen interactions. Pathog Dis. 2021 Apr 22;79(5). doi: 10.1093/femspd/ftab022. Review. PubMed PMID: 33792663; PubMed Central PMCID: PMC8062235.

O'Neal AJ, Butler LR, Rolandelli A, Gilk SD, Pedra JH. Lipid hijacking: a unifying theme in vector-borne diseases. Elife. 2020 Oct 29;9. doi: 10.7554/eLife.61675. Review. PubMed PMID: 33118933; PubMed Central PMCID: PMC7595734.

Chávez ASO*, O'Neal AJ*, Santambrogio L, Kotsyfakis M, Pedra JHF. Message in a vesicle - trans-kingdom intercommunication at the vector-host interface. J Cell Sci. 2019 Mar 18;132(6). doi: 10.1242/jcs.224212. Review. PubMed PMID: 30886004; PubMed Central PMCID: PMC6451414.

McClure Carroll EE, Wang X, Shaw DK, O'Neal AJ, Oliva Chávez AS, Brown LJ, Boradia VM, Hammond HL, Pedra JHF. p47 licenses activation of the immune deficiency pathway in the tick Ixodes scapularis. Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):205-210. doi: 10.1073/pnas.1808905116. Epub 2018 Dec 17. PubMed PMID: 30559180; PubMed Central PMCID: PMC6320499.