Our Research
Tick Immune System
Ticks have an innate immune system that responds to tick-borne microbes. Hemocytes (tick immune cells) comprise a crucial part of the tick’s immune system. However, we know very little about what they do. Using time-lapse microscopy and flow cytometry, we are characterizing the functions of hemocytes and how they ensure vector competence and fitness.
Conserved Tick and Mammalian Factors
Tick-borne microbes have to cycle between distinct hosts (ticks and mammals). By utilizing mouse models, human genetic data, and electronic health records, we are investigating host factors that facilitate the development of Lyme disease and other tick-borne infections.
Genetic Tools
Genetic tools to study tick immunity in vivo are virtually non-existent. We are developing genetic resources to track hemocyte dynamics in the presence and absence of tick-borne bacteria.